Drug+development+and+marketing

Mayorov Ivan Drug development and marketing

Drug development is a process, when a new drug goes to the market. But before it goes to the market it follows the particular pattern: product development, pre-clinical research (animals) and clinical trials (on humans, sometimes even over the law). It is very long process and it is also really very time consuming. Many companies spent millions on the drug development research. They test more than 10,000 - 30,000 different substances, before they will put one in market.



For example in 2003 report, average tax cost of approximately $800 million just to bring a new drug to market! If to look further, as the market develops and the substance of chemicals is getting more complex, the prices are increasing. Already after three years new report said that the cost of bringing drug to the market vary from around 500 million to 2,000 million dollars!



====The samples are taken in medical practices and clinics, generally in the form of venous blood from the arm or back of the hand. The test tubes are immediately provided with bar codes in order to guarantee unique identification. Couries fetch the specimens from the practices or clinics and take them to the laboratory in special transport boxes. Medical laboratory assistants then analyze the samples. The specimen is first of all prepared for analizis. Blood usually centrifuged (moved very fast in the circle) to obtain the serum (the blood product). Automatic pipette stations separate the primary samples. The analyzes are performed in an entry automated process, with the results being sent to the respective doctors using computerized support. The samples are then stored for a few days before they are destroyed.====

==== Firstly, because of effective drug product, which must deliver a new chemical entity (NCE) to the right place, at the right time and at the right concentration for patients to benefit. The goal of the early development team is to deliver a drug candidate that is suitable for full commercial development, supported by a data package demonstrating proof of safety, so efishancy. The project team must also recommend a drug product (dose strength) that will become the medicine that is available in the marketplace. ====

====Secondly, during the drug research, "multiplex bead assays" (MBA) allow simultaneous, just in time analysis of multiple targets within one reaction, providing more information and higher sensitivity, while using less sample than traditional ELISA assays. As the samples are bound to free-floating microspheres as a solid support, it can be tricky to wash and remove liquid from the microplates using traditional methods. These assays are dependent on supporting equipment in order to deliver the best quality results; inferior equipment can lead to inaccurate data, low bead recovery, or require additional testing.====

====The ethical issue about drug development are the clinical trials on animals or on humans, some times they are over coming some religions, not only law. Some religions think that these testings are the hood of devil, so they are not excepting it. Another example is that some green fighters, like Green Peace, are againsed the testing of drugs on animals, and even some times they can stop testings of the drugs by protests against them. But still the the drug testings are controled by the countries' law, which also needs to follow the international law, used by many countries.====

====The problem is that many swindlers are using the old drugs, and selling them by the name of the new brands. Customers are beliving many of this burglars and also think, that these drugs will help them, but usually it never helps, but causes even some hard illneses. At the last point it is not only causing the desises in humans it also not following the policy of the country, so actually that people are not only stilling money by not paying taxes, but also cause many problems for every one else.====

References: 1) [|www.msd.com.hk/.../e_ddp_introduction.html] 2) DiMasi J, Hansen R, Grabowski H (2003): "The price of innovation: new estimates of drug development costs"; 3) Adams C, Brantner V (2006): "Estimating the cost of new drug development: is it really 802 million dollars?";  4) www.tmw.ac.at and from Technical Museum of Vienna; 5) [] 6) [] 7) []

The end :~)